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KMID : 1123920040180061850
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Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 6 p.1850 ~ p.1855
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Study of Effects of Electroacupuncture on the Hippocampal Cholinergic Neuronal Activity
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Lee Kwang-Ro
Kang Se-Young
Yoon Ji-Won
Cho Chang-Hyun
Sung Kang-Keyng
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Abstract
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The purpose of this report is to investigate the electroacupuncture effect on the cholinergic neuronal activation in the hippocampal CA1 section. The electroacupuncture was performed on S36 of white rats and its consequencies were investigated by immunohistochemical method. Hippocampal CA1 sections of Sprague Dawley white male rats electroacupunctured on S36 at 20㎐ and 100㎐ are stained by cresyl violet to show that the values of 100㎐ and 20㎐ group increased significantly compared to sham group’s one. Especially, 100㎐ group shows stronger neuronal activation compared to 20㎐ group. Induction of AChE, a neurotransmitter, in hippocampal CA1 is increased significantly in 100㎐ and 20㎐ group compared to sham group. Especially 20㎐ group shows higher AChE immunoreaction than 100㎐ does, although it wasn’t significant enough. Induction of NGF(Nerve Growth Factor) in hippocampal CA1 sections was observed higher in 20㎐ and 100㎐ group than in sham group. Especially, 20㎐ group shows higher NGF immunoreaction compared to 100㎐. The facts above indicate that the eletroacupucture is effect to the cholinergic neuronal activation of hippocampus induced by focal ischemia.
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KEYWORD
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Hippocampal CA1 neuron, Cresyl violet stain, AChE, NGF
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